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Friday April 25, 2008
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=> IN THIS ISSUE!
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==> Editors' Ranting & or Warnings
==> Something To Think About
==> Health Thought for the day!
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Greetings and thank you for
being an optin subscriber!
The beautiful weather has mother nature in a
quandary here? We still have night freezes yet daytime summer
weather so fruit trees are in bloom early again, which means no fruit on
them again this year. We have come to realize fruit trees in this area are
strictly ornamental 99% of the time. That is one of the reasons we
are looking to resettle in an area where it isn't quite so
unpredictable, which is hard in this time of Global Warming. Our 35
years in Southern California spoiled us to fresh fruit and veggies year
round and it's been 16 years of trying to adjust to this unpredictable
area and still haven't adjusted to having to go elsewhere for organic
fruits... It is so much better when you can grow them in your own back
yard... Oh well, such is life... Here's wishing you a restful and
peaceful weekend. Be sure to take your day of rest and you body will
appreciate it!!!
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Something To Think About
============================
Study links
incontinence drugs with memory problems
Apr 17,2008
By CARLA K. JOHNSON
CHICAGO (AP) - Commonly used incontinence drugs may cause memory
problems in some older people, a study has found. "Our message is to be
careful when using these medicines," said U.S. Navy neurologist Dr. Jack
Tsao, who led the study. "It may be better to use diapers and be able to
think clearly than the other way around."
Urinary incontinence sometimes can be resolved with non-drug treatments,
he added, so patients should ask about alternatives. Exercises,
biofeedback and keeping to a schedule of bathroom breaks work for many.
U.S. sales of prescription drugs to treat urinary problems topped $3
billion in 2007, according to IMS Health, which tracks drug sales.
Bladder control trouble affects about one in 10 people age 65 and older,
according to the National Institute on Aging, which helped fund the
study. Women are more likely to be affected than men. Causes include
nerve damage, loss of muscle tone or, in men, enlarged prostate.
The research began after Tsao met a 73-year-old patient. Shortly after
starting an incontinence drug, she began hallucinating conversations
with dead relatives and having memory problems. Her thinking improved
when she stopped the drug for several months.
Tsao and his colleagues knew of similar reports. They decided to look at
a large group of people to see if they could measure an effect of these
and other medications that affect acetylcholine, a chemical messenger
that shuttles signals through the brain and the rest of the nervous
system. The drugs block some nerve impulses, such as spasms of the
bladder.
The findings, released Thursday at a meeting of the American Academy of
Neurology, come from an analysis of the medication use and cognitive
test scores of 870 older Catholic priests, nuns and brothers who
participated in the Religious Orders Study at Chicago's Rush University
Medical Center. The average age was 75.
Researchers tracked them for nearly eight years, testing yearly for
cognitive decline. They asked them to recite strings of numbers backward
and forward, to name as many different kinds of fruit as they could in
one minute and to complete other challenges during the annual testing.
Nearly 80 percent of the study participants took one or more of a class
of drugs called anticholinergics, including drugs for high blood
pressure, asthma, Parkinson's disease and incontinence drugs such as
Detrol and Ditropan.
The people who took the drugs had a 50 percent faster rate of cognitive
decline compared to those who didn't take any. The researchers
considered other risk factors for memory loss, such as age, and still
found the link. The researchers found no increased risk for the
memory-robbing disorder Alzheimer's in people taking the drugs.
The incontinence drugs were among the most potent and were the most
frequently taken of all the anticholinergics in the study. That's why
the researchers believe they are driving the memory problems, Tsao said.
Some experts said the research supports previous observations and is
helpful because it measures the size of the effect.
"This paper adds important new data to the picture," said Dr. Elaine
Perry of Newcastle University in England, who has done similar research
but was not involved in the new study.
More research is needed on the effects of anticholinergic drugs on
memory, Tsao said. Doctors should do baseline cognitive testing on
patients before prescribing the drugs, he recommended.
A representative of Pfizer Inc. (PFE), maker of the top-selling Detrol,
said patients should always talk to their doctors about problems while
taking medication.
"Detrol has been on the market since 1998. It has been prescribed more
than 100 million times worldwide," said Ponni Subbiah, Pfizer's vice
president of medical affairs, in an e-mail response to questions.
"Confusion and memory impairment were added to prescribing information
for Detrol in 2006," Subbiah said. "after some patients reported the
problems. Since the reports weren't part of a medical study, the
frequency of events and the role of Detrol in their causation cannot be
reliably determined," he said.
American Academy of
Neurology
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TODAY'S HEALTH TIP
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Women Can't win with Migraine
Headaches
April 21, 2008
By Meghan Yost, Ivanhoe Health Correspondent
ORLANDO, Fla. (Ivanhoe Newswire) -- A headache is more than just irritating --
it could also be harmful to your health. New research reveals women who suffer
from weekly migraines are more likely to have a stroke than women with fewer or
no migraines, while those with less frequent migraines may have a higher chance
of suffering a heart attack.
For 12 years, researchers followed 27,298 women health professionals in the
United States, age 45 and older. At the start of the study, none had
cerebrovascular disease. The data revealed women who had migraines at least
weekly were three times more likely to suffer a stroke, while those who had
migraines less than monthly were one-and-a-half times more likely to have a
heart attack.
"Nobody knows why there's an association with strokes and heart attacks in
people who have migraines," Brain Howard Kahn, M.D., F.A.C.C., a cardiologist at
the Heart Center at Overlea, an affiliate of Mercy Medical Center in Baltimore,
Md., who was not affiliated with the study, told Ivanhoe. However, he says there
is evidence that the standard drugs used to treat migraine headaches carry
cardiovascular risks. "The medications actually cause constrictions of blood
vessels. So if you have a blockage in your arteries, [the medications] constrict
the blood vessel further and that can, in fact, precipitate a heart attack."
Dr. Kahn says the take-home message for patients with migraines is they should
watch their health closely. ?I think if they have other risk factors they need
to modify those even further. So if you?re smoking, you need to stop smoking; if
you have high blood pressure, you need to get it under control; if you're
diabetic, get your sugars controlled; treat your cholesterol aggressively and
exercise.?
SOURCE: Ivanhoe interview with Brain Howard Kahn, M.D., F.A.C.C.; Presented at
the American Academy of Neurology 60th Anniversary Annual Meeting in Chicago,
April 12 - 19, 2008
LENA'S COMMENT: The study was done on women only but you can bet men
suffer the same fate! Before I got to the third paragraph I had already figured
out why cardiovascular disease! Weekly headaches means lots of medication and
every medication prescribed for headaches especially migraines deplete the body
of nutrients, which weaken the heart also creates the atmosphere for a build up
of inflammation in the arteries. No, I'm not clairvoyant, just been around
medicine a long time!
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FOOD OF THE WEEK
~^~^~^~^~^~^~^~^~^~^~^
The Ultimate
Prickly Ananas comosus Merr!
Four years, this month, has passed since my visit to one
of the large areas known for its great tasting Ananas comosus,
Hawaii... So it's only natural that I should think about this particular
food at this time each year and my marvelous visit there. I also
remember eating a lot of these and enjoying every morsel! Yesterday I
was able to buy one of these glorious fruits from Hawaii and today will
be spent enjoying it. In our area I so seldom find one from the great
state of Hawaii as they are just different in taste from any other
country. Maybe it's the great air there or the weather, I don't know but
they are truly the tastiest of all Ananas comosus Merr!
Christopher Columbus discovered this delectable food growing on the
island of Guadeloupe in 1493 and took them back to Spain. It became very
popular in Europe by the 1600s.
What is Ananas comosus Merr? Pineapple! The exceptional juiciness
and vibrant tropical flavor of pineapple that balances the tastes of
sweet and tart make them only second to bananas as America?s favorite
tropical fruit. Although the Hawaiian season for pineapple runs from
March through June, they are available year-round in some local markets;
just not as evenly ripe as those harvested fresh in Hawaii but they can
be ordered online from Hawaii to get that same great taste.
Bromelain, the great health property contained in pineapples, has been
used for hundreds of years as a digestive aid, and to treat inflammation
and other health problems. Recently, bromelain has been investigated for
possible anticancer activity and now studies show it to contain protease
that is a great blood thinner cholesterol lowering agent, thereby
helping in preventing heart disease and stroke. Now all these will
require daily consumption of pineapple and a very large portion.
Pineapple was a culinary favorite of the fierce Carib Indians who lived
on islands in the sea that still bears their name.
High in fiber and very rich in minerals and vitamins, although not as
great amounts as many years ago but still some: raw pineapple contains
*Calcium, a mineral, is used for building bones and teeth and in
maintaining bone strength. Calcium is also used in muscle contraction,
blood clotting, and maintenance of cell membranes.
*Iron, Necessary for production hemoglobin, and oxygenation of
red blood cells, builds up blood quality, and increases resistance as
well as increasing energy production.
*Magnesium, Key substance in proper functioning of nerves and
muscles and healthy maintenance of bones. Helps protect the arterial
lining from the stress of sudden blood pressure changes.
*Phosphorus, Essential for utilization of carbohydrate, fats and
proteins for growth, maintenance, repair of cells, and energy
production. Necessary for proper skeletal growth, tooth development,
kidney functioning and transference of nerve impulses.
*Potassium, Essential for muscles, nerves and heart. Aids in
proper maintenance of mineral balance of blood, as well as stable blood
pressure. Works with sodium to regulate the body's water balance.
*Sodium, The mineral is needed to maintain proper water balance
and blood pH. The mineral aids in the transmission of nerve impulses,
production of hydrochloric acid in the stomach, muscle function and
immune system maintenance.
*Zinc, important in prostate gland functions and the growth of
reproductive organs. The mineralization of bone, a healthy immune
system, the digestion of proteins, the acuity of taste and smell,
detoxification of free radical promoting metals, collagen formation and
wound healing, all depend on zinc. It assists in the transportation of
vitamin A in the blood. Sufficient intake and absorption of zinc are
needed to maintain the proper concentration of vitamin E in the blood.
*Copper, its functions involve the development and maintenance of
the cardiovascular, skeletal and the nervous system, including the
brain. The development and maintenance of the red blood cells and
healthy skin and hair also depend upon copper. Found in all the tissues,
the mineral is most concentrated in the brain, heart, kidney, and liver.
*Manganese, essential cofactor in a number of enzymes important
in energy production and antioxidant defenses.
*Selenium, enhances the immune system, normal development of the
fetus during pregnancy, improving arthritic symptoms, and protecting the
skin from UV rays. A deficiency could result in birth defects, increased
risk of cancer, heart and liver diseases, Down's syndrome and
fibrocystic breast disease.
A host of vitamins;
Vitamin C Thiamin
Vitamin B1,
Riboflavin,
Niacin,
Pantothenic acid,
Vitamin B-6,
Folate,
Folic acid,
Vitamin B-12,
Vitamin A,
Retinol,
Vitamin A,
Vitamin E,
Tocopherol.
Along with Amino acids such as Tryptophan, Threonine, Isoleucine,
Leucine, Lysine, Methionine, Cystine, Phenylalanine, Tyrosine, Valine,
Arginine,Histidine, Alanine, Aspartic acid, Glutamic acid, Glycine,
Proline and Serine.
Low in calories high in healthy nutrients! Pineapple is best eaten
alone between meals or its enzymes will be used up digesting food and
not benefiting your body as well as it could.
Selecting, storing and using pineapple:
Look for pineapples that are heavy for their size. While larger
pineapples will have more edible flesh, there is usually no difference
in quality between a small and large size pineapple. Pineapples should
be free of soft spots, bruises and darkened ?eyes,? all of which may
indicate that the pineapple is past its prime. Choose fruit with a
fragrant sweet smell at the stem end. Avoid pineapple that smells musty,
sour or fermented.
Pineapple can be left at room temperature for one or two days before
serving. While this process will not make the fruit any sweeter, it will
help it to become softer and juicier. Since they are very perishable,
you should watch closely during storing period to ensure that they do
not spoil. After two days, if you are still not ready to consume the
pineapple, you should wrap it in a perforated plastic bag and store it
in the refrigerator where it will keep for a maximum of three to five
more days.
Pineapple that has been cut up should be stored in the refrigerator in
an airtight container. It will stay fresher and retain more taste and
juiciness if you also place some liquid, preferably juice from the
pineapple, in the container. Although pineapple can be frozen, this
process greatly affects its flavor.
Our favorite way of eating pineapple is fresh and raw, can't beat it for
great taste and enjoyment.
Until next week's food, eat to enjoy greater health. My husband loves
pineapple pie.
Word of caution: If you are taking
prescription/chemical blood thinners eat pineapple or drink pineapple
juice be sure to monitor your blood closely
for too much thinning as the bromelain has been known to cause thinning
of the blood without help and add that to a ingested blood thinner could
be a danger!
Enjoy!
Lena
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HEALTH TODAY
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CANCER DRUG TRIALS:
QUITTING WHILE YOU'RE AHEAD
April 20, 2008
According to the report, published in Annals of Oncology, an
increasing number of cancer drug clinical trials are being
stopped early, on the basis of very preliminary (and possibly
misleading) evidence, and this ultimately puts patients in
general at risk.
Researchers at the Mario Negri Institute for Pharmacological
Research in Milan, looked at all cancer trials published in the
decade between 1997 and 2007 in three major medical journals.
They identified 25 that were stopped early because the drugs in
question appeared, initially at least, to be working well. The
trials' reviewers thereupon demanded an early trial closure so
that all participating patients could get the new medicines as
soon as possible. Significantly, the Milan researchers found
that about 80 percent of trials that are stopped prematurely
were linked to an application for a marketing license in Europe
or the United States.
"That suggests that companies have a commercial interest in
stopping these trials, which may not be good for patients," said
Giovanni Apolone, MD, Head of the Laboratory of Translational
and Outcome Research the Mario Negri Institute. "Without enough
information [i.e., the kind that can only come from a completed
trial, ed.], we don't know if patients are really benefiting
from these new drugs." Dr. Apolone is an important voice in the
field of medical ethics. In addition to his position at Mario
Negri, he is Vice-President of the Ethics Committee of the
European Institute of Oncology and is a National Expert at the
European Agency for the Evaluation of Medicinal products (EMEA)
in London (UK).
Apolone also told the British newspaper The Independent: "This
suggests a commercial component in stopping trials prematurely.
We are aware that trials stopped early because they are showing
benefit may result in the identification of promising new
treatments for patients. However, findings obtained in this way
require subsequent confirmation. Without such evidence, unsafe
and ineffective drugs could be marketed and patients' health
could well be jeopardized."
Some of the drugs whose trials were stopped early are among the
most heavily promoted new treatments, including Herceptin (trastuzumab)
for breast cancer, Avastin (bevacizumab) for colon, kidney and
breast cancer, Camptosar (irinotecan) for lung and bowel cancer,
Sutent (sunitinib) for kidney and gastrointestinal cancer,
Nexavar (sorafenib) for kidney cancer, and TaxolCarbo (carboplatin)
for ovarian and lung cancer (Laurance 2008).
Dr Apolone said it could take years for the long-term benefits
or dangerous adverse effects of a drug to become evident, but
the average duration of the 25 trials that were stopped early
was just 30 months. Five of these trials had enrolled less than
40 per cent of the planned number of patients. This means that
decisions on drug approval and availability were based on
under-powered clinical trials that were halted well before
information on long term safety and effectiveness could be
gathered.
In the online edition of Annals of Oncology, the Milan
researchers added: "If a trial is evaluating long-term efficacy
of a treatment of conditions such as cancer, short-term benefits
- no matter how significant statistically - may not justify
early stopping. Data on disease recurrence and progression, drug
resistance, metastasis, or adverse events, all factors that
weigh heavily in the benefit/risk balance, could easily be
missed" (Trotta 2008).
Stuart Pocock, professor of medical statistics at the London
School of Hygiene and Tropical Medicine, also told The
Independent that stopping trials that showed early evidence of
benefit skews the overall results and exaggerates the benefits
of new anticancer drugs.
"Overall, there is an underlying bias towards exaggeration [of
the results]. We can pretty reliably claim there is exaggeration
going on. This is not as sober an environment as it should be.
It has an aura of hot-headedness about it" (Laurance 2008).
Defenders of the early trial closure system say that these
decisions to pull the plug on cancer drug trials are not made by
pharmaceutical companies, and not even by the researchers who
head the trials. They are generally made by outside data
monitoring committees, which routinely review trial information
and periodically assess progress. The data monitoring committees
then make recommendations to the sponsoring pharmaceutical
companies. Indeed, in the Apolone study, 19 out of the 25 trials
halted early were overseen by such independent data monitoring
committees.
While ideally a data monitoring committee should not include any
members with contractual or financial ties to the trial's
sponsor or to the contract research organization conducting the
trial, it can be difficult to find experts in the field who have
no such ties. Furthermore, there is nothing to say that such
outside experts are not ideologically biased in favor of quickly
approving new anticancer drugs. A lot of oncologists feel that
the more new drugs that are available in their armamentarium, by
definition the better off they and their patients will be.
The system is thus designed in such a way that evaluators
generally rush to judgment to approve new agents.
Ralph W. Moss PhD
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ENVIRONMENTAL REPORT
~^~^~^~^~^~^~^~^~^~^~^~~^~^~^
Formaldehyde Exposure Linked With ALS In US Study
April 17, 2008
by Julie Steenhuysen
CHICAGO - Exposure to the widely used chemical formaldehyde may
raise one's risk of getting amyotrophic lateral sclerosis (ALS),
or Lou Gehrig's disease, US researchers said on Wednesday.
A large study examining a possible association between ALS and
12 types of chemicals turned up the link, which researchers said
needs to be confirmed in other studies.
While they found no significant link between ALS and most
chemicals, including pesticides and herbicides, they found
people who had been regularly exposed to formaldehyde were 34
percent more likely to develop ALS.
"We really went into it interested in the pesticide and
herbicide question," said Marc Weisskopf, a researcher at the
Harvard School of Public Health who presented his findings at a
meeting of the American Academy of Neurology in Chicago.
"It has not been previously looked at in ALS," he said.
The study involved more than 1,100 people enrolled in a cancer
prevention study who died of ALS. They were asked about their
exposure to formaldehyde and other chemicals in 1982, and then
followed for 15 years.
Weisskopf said certain jobs seemed to have a much higher risk.
They included beautician, pharmacist, mortician, chemist, lab
technician, dentist, fireman, photographer, printer, nurse,
doctor and veterinarian.
"People in those jobs had about a 30 percent higher rate of
ALS," he said.
Weisskopf said the finding could still just be chance, but he
did find that the more exposure to the chemical people reported,
the more likely they were to develop ALS, which strengthened the
association.
"Ideally, we would like to see people start looking at this and
see whether the finding holds up in other settings," Weisskopf
said in a telephone interview.
Formaldehyde is used in particleboard and other wood products,
permanent press fabrics, glues and household products such as
cosmetics and shampoo. It is also used to preserve tissue in
laboratories and mortuaries, and as a disinfectant.
In 1987, it was classified as a probable human carcinogen at
high exposure levels.
ALS progressively kills nerve cells that control muscle
movements known as motor neurons in the brain and spinal cord.
It is sometimes called Lou Gehrig's disease for taking the life
of the famous New York Yankees baseball player in 1941.
About 5,600 people in the United States are diagnosed with ALS
each year, according to the ALS Association.
REUTERS NEWS
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